Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?

Nephron. 2019;143(3):179-183. doi: 10.1159/000499940. Epub 2019 Apr 18.


The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Effects of RAAS antagonists are variable in chronic or acute conditions. The aim of this review is to discuss the renal and systemic effects of the RAAS, and its modulation, in acute situations.

Keywords: Acute conditions; Acute kidney injury; Antagonists; Chronic conditions; Renal fibrosis; Renin-angiotensin-aldosterone system.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / drug therapy*
  • Acute Kidney Injury / physiopathology*
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Animals
  • Fibrosis
  • Humans
  • Kidney / pathology
  • Mineralocorticoid Receptor Antagonists / therapeutic use
  • Renin-Angiotensin System / drug effects*
  • Renin-Angiotensin System / physiology*


  • Angiotensin-Converting Enzyme Inhibitors
  • Mineralocorticoid Receptor Antagonists