In vitro effects of Bacillus subtilis on the immune response

Chemioterapia. 1986 Dec;5(6):404-7.


The authors evaluated the in vitro effects of Bacillus subtilis on the following parameters of the immune response: mitogenic T cell proliferation (by PHA and OKT3) and mitogenic-induced lymphokine production (IL-2 and IFN-gamma). The spores of Bacillus subtilis did not influence the immune response, while its vegetative forms enhanced mitogenic-induced T cell proliferation. Both spores and vegetative forms did not modify lymphokine production.

MeSH terms

  • Adult
  • Bacillus subtilis / immunology*
  • Female
  • Humans
  • Interferon-gamma / biosynthesis*
  • Interleukin-2 / biosynthesis*
  • Lymphocyte Activation*
  • Male
  • Mitogens / pharmacology
  • Spores, Bacterial / immunology
  • T-Lymphocytes / immunology


  • Interleukin-2
  • Mitogens
  • Interferon-gamma