Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis

Exp Neurol. 1987 Feb;95(2):323-35. doi: 10.1016/0014-4886(87)90142-7.


Apolipoprotein E is expressed in neurofibrosarcoma and Schwannoma cell cultures derived from two patients with different types of neurofibromatosis, but not in six cell cultures derived from the benign neurofibromatosis neurofibromas. In addition, a cell culture derived from a nonneurofibromatosis human malignant astrocytoma showed apolipoprotein E expression. Although all cells in either the neurofibrosarcoma or Schwannoma cultures appeared morphologically similar (suggesting homogeneity), apolipoprotein E was immunochemically detected in the perinuclear region of only half of the cells. Thus, production of apolipoprotein E in neurofibromatosis-associated neurofibroma tumors may be a marker for a specific subclass of transformed cells. The expression of apolipoprotein E in glial cell neoplasms is possibly related to an alteration in their lipid metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Apolipoproteins E / biosynthesis*
  • Astrocytoma / metabolism
  • Brain Neoplasms / metabolism*
  • Chemical Precipitation
  • Child
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Fluorescent Antibody Technique
  • Histocytochemistry
  • Humans
  • In Vitro Techniques
  • Male
  • Microscopy, Phase-Contrast
  • Middle Aged
  • Neurilemmoma / metabolism*
  • Neurofibroma / metabolism*
  • Neurofibromatosis 1 / metabolism*


  • Apolipoproteins E