Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction

Adv Biol Regul. 2019 May:72:7-21. doi: 10.1016/j.jbior.2019.04.001. Epub 2019 Apr 6.


Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the development of many diseases. PPIn are phosphorylated derivatives of phosphatidylinositol and consist of seven species with different phosphate combinations. PPIn signal by recruiting proteins via canonical domains or short polybasic motifs. Although their actions are predominantly documented on cytoplasmic membranes, six of the seven PPIn are present within the nucleus together with the PPIn kinases, phosphatases and phospholipases that regulate their turnover. Importantly, the contribution of nuclear PPIn in the regulation of nuclear processes has led to an increased recognition of their importance compared to their more accepted cytoplasmic roles. This review summarises our knowledge on the identification and functional characterisation of nuclear PPIn-effector proteins as well as their mode of interactions, which tend to favour polybasic motifs.

Keywords: Electrostatic interactions; K/R motif; Nucleus; Phosphoinositides; Polybasic motif; Polyphosphoinositides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / enzymology
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Humans
  • Phosphatidylinositol Phosphates / metabolism*
  • Phospholipases / genetics
  • Phospholipases / metabolism
  • Phosphoric Monoester Hydrolases / genetics
  • Phosphoric Monoester Hydrolases / metabolism


  • Phosphatidylinositol Phosphates
  • Phospholipases
  • Phosphoric Monoester Hydrolases