Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast

Parasitol Int. 2020 Feb;74:101918. doi: 10.1016/j.parint.2019.04.015. Epub 2019 Apr 18.

Abstract

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. For this assessment, asthmatic and non-asthmatic children (ISAAC questionnaire) were submitted to parasitological tests and blood samples were cultured (mitogen stimulation) for cytokine measurements in the supernatant. Asthma frequencies were similar in infected and uninfected children, but IL-4, IL-6, TNF-α and IL-10 levels were high in the infected asthmatic children. Additionally, infected non-asthmatic children exhibited high levels of these cytokines in relation to uninfected non-asthmatic children; however, cytokine levels were lower when compared with infected and asthmatic children. Therefore, T. trichiura infection positively modulated the pro- and anti-inflammatory cytokines in asthmatic children, but a background of asthma seemed to narrow the production of cytokines induced by this helminth.

Keywords: Asthma; Children; Cytokines; Helminth.

MeSH terms

  • Animals
  • Asthma / immunology
  • Asthma / parasitology*
  • Brazil
  • Child
  • Child, Preschool
  • Cytokines / blood*
  • Cytokines / immunology
  • Female
  • Humans
  • Hypersensitivity / immunology
  • Hypersensitivity / parasitology
  • Immunity, Cellular
  • Male
  • Trichuriasis / immunology*
  • Trichuris

Substances

  • Cytokines