Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update

Radiother Oncol. 2019 May;134:1-9. doi: 10.1016/j.radonc.2019.01.018. Epub 2019 Jan 30.

Abstract

Background and purpose: In 2000, a panel of experts published a proposal for the selection of lymph node target volumes for definitive head and neck radiation therapy (Radiother Oncol, 2000; 56: 135-150). Hereunder, this selection is updated and extended to also cover primary sites not previously covered.

Patients and methods: The lymphatic spread of head and neck cancers into neck lymph nodes was comprehensively reviewed based on radiological, surgical and pathological literature regarding both initial involvement and patterns of failure. Then a panel of worldwide head and neck radiotherapy experts agreed on a consensus for the selection of both high- and low-risk lymph node target volumes for the node negative and the node positive neck.

Results: An updated selection of lymph node target volumes is reported for oral cavity, oropharynx, hypopharynx, larynx, nasopharynx, paranasal sinuses, nasal cavity and carcinoma of unknown primary as a function of the nodal staging (UICC 8th edition).

Conclusions: The selection of lymph node target volumes for head and neck cancers treated with IMRT/VMAT or other highly conformal techniques (e.g. proton therapy) requires a rigorous approach. This updated proposal of selection should help clinicians for the selection of lymph nodes target volumes and contribute to increase consistency.

Keywords: Definitive radiotherapy; Head and neck cancers; Lymph node target volumes; Selection.

Publication types

  • Practice Guideline

MeSH terms

  • Head and Neck Neoplasms / pathology
  • Head and Neck Neoplasms / radiotherapy*
  • Head and Neck Neoplasms / surgery
  • Humans
  • Lymph Nodes / pathology
  • Lymph Nodes / radiation effects*
  • Lymphatic Metastasis
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Radiotherapy Planning, Computer-Assisted / standards*
  • Radiotherapy, Adjuvant / methods
  • Radiotherapy, Adjuvant / standards
  • Squamous Cell Carcinoma of Head and Neck / pathology
  • Squamous Cell Carcinoma of Head and Neck / radiotherapy
  • Squamous Cell Carcinoma of Head and Neck / surgery