Cytokine-induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Ann N Y Acad Sci. 2020 Apr;1466(1):24-38. doi: 10.1111/nyas.14059. Epub 2019 Apr 21.

Abstract

Peripheral blood hematopoietic stem and progenitor cells (HSPCs), mobilized by granulocyte colony-stimulating factor, are widely used as a source for both autologous and allogeneic stem cell transplantation. The use of mobilized HSPCs has several advantages over traditional bone marrow-derived HSPCs, including a less invasive harvesting process for the donor, higher HSPC yields, and faster hematopoietic reconstitution in the recipient. For years, the mechanisms by which cytokines and other agents mobilize HSPCs from the bone marrow were not fully understood. The field of stem cell mobilization research has advanced significantly over the past decade, with major breakthroughs in the elucidation of the complex mechanisms that underlie stem cell mobilization. In this review, we provide an overview of the events that underlie HSPC mobilization and address the relevant cellular and molecular components of the bone marrow niche. Furthermore, current and future mobilizing agents will be discussed.

Keywords: G-CSF; hematopoietic stem cells; stem cell mobilization; stem cell niche.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow / physiology
  • Cell Communication / physiology*
  • Cytokines / pharmacology
  • Cytokines / physiology*
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Hematopoietic Stem Cell Mobilization* / methods
  • Hematopoietic Stem Cell Mobilization* / trends
  • Hematopoietic Stem Cell Transplantation / methods
  • Hematopoietic Stem Cell Transplantation / trends
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Stem Cell Niche / physiology*

Substances

  • Cytokines
  • Granulocyte Colony-Stimulating Factor