Antiviral Activities of Silymarin and Derivatives

Molecules. 2019 Apr 19;24(8):1552. doi: 10.3390/molecules24081552.


Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.

Keywords: antiviral; drug development; flavonolignans; silymarin.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Chikungunya virus / drug effects
  • Dengue Virus / drug effects
  • Flavivirus / drug effects
  • Flavonolignans / chemistry
  • Flavonolignans / pharmacology*
  • HIV / drug effects
  • Hepacivirus / drug effects
  • Silymarin / chemistry
  • Silymarin / pharmacology*
  • Togaviridae / drug effects


  • Antiviral Agents
  • Flavonolignans
  • Silymarin