[Therapeutic options for oligoprogressive non-small cell lung cancer]

Rev Mal Respir. 2019 Apr;36(4):519-526. doi: 10.1016/j.rmr.2018.04.011. Epub 2019 Apr 19.
[Article in French]


Lung cancer is the leading cause of cancer-related mortality and more than half of the cases are diagnosed at a metastatic stage. Major progress in terms of systemic treatments has been achieved in recent decades. Access to new anti-PD-(L) 1 immunotherapies and targeted therapies for non-small cell lung cancer (NSCLC) with oncogenic addiction such as EGFR mutation or ALK rearrangement have led to improved outcomes. Patients with limited progression of their disease during systemic treatment may be a particular subgroup. This oligoprogressive state is characterized by a limited number of sites in progression, implying that the other sites remain controlled and therefore sensitive to systemic treatments. The advent of non-invasive techniques such as stereotactic radiotherapy, radiofrequency, and mini-invasive surgery has led to a precise re-evaluation of local ablative treatments in this situation. Local treatment of the oligoprogressive lesion(s) may allow modification of the natural history of the disease, maintenance of effective systemic targeted treatment and, ultimately, to improved survival. Data validating an aggressive local therapeutic approach in oligoprogressive NSCLC patients are currently limited and essentially retrospective. Several international trials are underway that could confirm the clinical benefit of radical local treatment in oligoprogressive advanced NSCLC patients.

Keywords: Cancer du poumon; Chemotherapy; Chimiothérapie; Chirurgie; Interventional radiology; Irradiation; Lung cancer; Oligometastatic; Oligométastase; Oligoprogression; Radiologie interventionnelle; Surgery.

Publication types

  • Review

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Choice Behavior
  • Combined Modality Therapy
  • Disease Progression
  • Humans
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / therapy*
  • Neoplasm Staging
  • Pneumonectomy / methods
  • Protein Kinase Inhibitors / therapeutic use
  • Radiosurgery / methods
  • Radiotherapy / methods


  • Protein Kinase Inhibitors