Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May 18;40(3):146-150.
doi: 10.24272/j.issn.2095-8137.2019.035. Epub 2019 Mar 28.

Specific Function and Modulation of Teleost Monocytes/Macrophages: Polarization and Phagocytosis

Affiliations
Free PMC article
Review

Specific Function and Modulation of Teleost Monocytes/Macrophages: Polarization and Phagocytosis

Xin-Jiang Lu et al. Zool Res. .
Free PMC article

Abstract

Macrophages exist in most tissues and play a variety of functions in vertebrates. Teleost fish species are found in most aquatic environments throughout the world and are quite diverse for a group of vertebrate animals. Due to whole genome duplication and environmental adaptation, teleost monocytes/macrophages possess a variety of different functions and modulations compared with those of mammals. A deeper understanding of teleost monocytes/macrophages in the immune system will not only help develop teleost-specific methods of disease prevention but will also help improve our understanding of the various immune mechanisms in mammals. In this review, we summarize the differences in polarization and phagocytosis of teleost and mammalian macrophages to improve our understanding of the various immune mechanisms in vertebrates.

Keywords: Comparative immunology; Cytokine production; Monocytes /Macrophages; Phagocytosis; Teleost.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Differences in monocytes/macrophages between mammals and teleosts

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Aghaallaei N, Bajoghli B, Schwarz H, Schorpp M, Boehm T. 2010. Characterization of mononuclear phagocytic cells in medaka fish transgenic for a cxcr3a: gfp reporter. Proceedings of the National Academy of Sciences of the United States of America, 107(42): 18079–18084. - PMC - PubMed
    1. Arranz A, Doxaki C, Vergadi E, Martinez De La Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. 2012. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proceedings of the National Academy of Sciences of the United States of America, 109(24): 9517–9522. - PMC - PubMed
    1. Bennani N, Schmid-Alliana A, Lafaurie M. 1995. Evaluation of phagocytic activity in a teleost fish, Dicentrarchus labrax . Fish & Shellfish Immunology, 5(3): 237–246.
    1. Bilej M, De Baetselier P, Beschin A. 2000. Antimicrobial defense of the earthworm. Folia Microbiologica, 45(4): 283. - PubMed
    1. Blidner AG, Méndez-Huergo SP, Cagnoni AJ, Rabinovich GA. 2015. Re-wiring regulatory cell networks in immunity by galectin-glycan interactions. Febs Letters, 589(22): 3407–3418. - PubMed
Feedback