Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins - a prospective randomised study

Vasa. 2019 Aug;48(5):405-412. doi: 10.1024/0301-1526/a000792. Epub 2019 Apr 24.


Background: Endovenous cyanoacrylate ablation is a new technique for the treatment of clinically symptomatic venous insufficiency. The results of a prospective comparative study of cyanoacrylate glue versus endovenous laser ablation for the management of incompetent great saphenous veins are presented. Patients and methods: A total of 400 subjects were treated with cyanoacrylate ablation or endovenous laser ablation between April 2014 and April 2016. The preprocedural, procedural, postprocedural, and follow-up data were recorded and compared. Results: There were 208 procedures in cyanoacrylate ablation group (CAA) and 204 in endovenous laser ablation group (EVLA). Operative time was 13 ± 3.4 minutes in the CAA and 31.7 ± 8.8 minutes in the EVLA (< 0.001). All procedures in both groups were successful, and the target vein segments were fully occluded at the end of the procedure. Periprocedural pain was less in the CAA (< 0.001). Enduration, ecchymosis, and paresthesia rates were significantly higher in the EVLA (< 0.001). The mean length of follow-up was 14 months (range 10-16). The 3, 6 and 12 months closure rates were 97.4%, 95.6%, and 94.1% for EVLA and 98.6%, 97.1% and 96.6% for CAA respectively. In both groups, the Venous Clinical Severity Score and Chronic Venous Insufficiency Quality of Life Questionnaire with declined significantly with no difference between groups. Conclusions: Management of incompetent great saphenous veins both endovenous cyanoacrylate ablation and laser ablation results in high occlusion rates. Endovenous cyanoacrylate ablation technique is fast and simple with low periprocedural pain that does not require tumescent anesthesia and compression stockings.

Keywords: Chronic venous insufficiency; ablation; cyanoacrylate; laser; varicose veins.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Cyanoacrylates
  • Humans
  • Laser Therapy*
  • Prospective Studies
  • Quality of Life
  • Saphenous Vein
  • Treatment Outcome
  • Varicose Veins*
  • Venous Insufficiency*


  • Cyanoacrylates