[Synergistic action of lentinan (LNT) with endocrine therapy of breast cancer in rats and humans]

Gan To Kagaku Ryoho. 1987 Feb;14(2):516-22.
[Article in Japanese]


With the aim of clarifying the nature of the synergistic action of LNT with endocrine therapy for mammary tumor, the effect of LNT post-treatment was investigated in rats with DMBA-induced mammary tumors and also in patients with recurrent breast cancer. LNT injection following surgical therapy (Ax + Ox) resulted in a much greater regression of tumor growth than that obtained by surgery alone, but not after medical therapy (Tamoxifen). Image analysis using an immunohistochemical technique revealed that LNT-surgical therapy resulted in marked atrophy of tumors and as well as intense infiltration of T cells, B cells and macrophages into the stroma around the tumor. Blood prolactin level was greatly reduced by LNT injection. A clinical randomized controlled study demonstrated the efficacy and safety of LNT post-treatment with surgical therapy in 33 patients with recurrent breast cancer. The mode of the synergistic action of LNT in combination with endocrine therapy on hormone-dependent tumors was discussed.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Adrenalectomy
  • Adult
  • Animals
  • Breast Neoplasms / therapy*
  • Combined Modality Therapy
  • Drug Synergism
  • Female
  • Humans
  • Lentinan / therapeutic use*
  • Mammary Neoplasms, Experimental / chemically induced
  • Mammary Neoplasms, Experimental / therapy*
  • Middle Aged
  • Ovariectomy
  • Polysaccharides / therapeutic use*
  • Random Allocation
  • Rats
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis
  • Tamoxifen / therapeutic use*


  • Polysaccharides
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Tamoxifen
  • Lentinan
  • 9,10-Dimethyl-1,2-benzanthracene