The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

Biomed Res Int. 2019 Mar 20;2019:8086257. doi: 10.1155/2019/8086257. eCollection 2019.


Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Autoimmune Diseases / immunology*
  • Humans
  • Immunologic Factors / immunology*
  • Immunologic Factors / pharmacology
  • Thioctic Acid / immunology*
  • Thioctic Acid / pharmacology


  • Antioxidants
  • Immunologic Factors
  • Thioctic Acid