Association of SNPs in the OBFC1 gene and laryngeal carcinoma in Chinese Han male population

Int J Clin Oncol. 2019 Sep;24(9):1042-1048. doi: 10.1007/s10147-019-01442-w. Epub 2019 Apr 23.

Abstract

Background: Laryngeal carcinoma (LC) is one of common diagnosed head and neck malignancies. Telomere length has been reported involved in malignant transformation and tumorigenesis. We speculate that single nucleotide polymorphisms (SNPs) in telomere length-related gene oligonucleotide/oligosaccharide-binding folds containing 1 (OBFC1) may have an association with LC in Chinese Han male population.

Methods: To prove this hypothesis, we performed a case-control study to analyze the OBFC1 polymorphisms in 172 LC patients and 180 healthy controls. A total of five SNPs (i.e., rs9325507, rs3814220, rs12765878, rs11191865, rs9420707) were selected for further genotyping.

Results: There was a significant difference in rs9325507 T allele frequency (OR = 0.88, 95% CI 0.64-1.21, P = 0.036) and rs11191865 A allele frequency (OR = 0.86, 95% CI 0.62-1.18, P = 0.009) between patient and control groups. In addition, the rs9325507 T/C genotype, rs3814220 G/A genotype, rs12765878 C/T genotype and rs11191865 A/G genotype had a lower risk of LC based on the results of logistic regression model analysis.

Conclusions: The results indicate a potential association between OBFC1 and LC risk in Chinese Han male population. Further work is required to confirm these results and explore the mechanisms of these effects.

Keywords: Laryngeal carcinoma; OBFC1; Single-nucleotide polymorphisms; Telomere length.

MeSH terms

  • Aged
  • Asians / genetics
  • Case-Control Studies
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Laryngeal Neoplasms / genetics*
  • Laryngeal Neoplasms / mortality
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Telomere-Binding Proteins / genetics*

Substances

  • Stn1 protein, human
  • Telomere-Binding Proteins