Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis

Eur J Immunol. 2019 Aug;49(8):1291-1294. doi: 10.1002/eji.201948147. Epub 2019 May 2.

Abstract

Infection with helminths can protect against the development of autoimmune diseases and this has been associated with induction of anti-inflammatory innate immune responses and Tregs. Here, we demonstrate that helminth-derived products can directly target T cells, especially IL-17-secreting γδ T cells that play a key pathogenic role in CNS autoimmune disease.

Keywords: Experimental autoimmune encephalomyelitis; Fasciola hepatica; IL-17; Th17; γδ T cell.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Helminth / immunology
  • Cell Extracts / immunology
  • Cells, Cultured
  • Cytokines / metabolism
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental / therapy*
  • Fasciola hepatica / immunology*
  • Fascioliasis / immunology*
  • Humans
  • Immunosuppression
  • Mice
  • Multiple Sclerosis / therapy*
  • Myelin-Oligodendrocyte Glycoprotein / immunology
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism
  • T-Lymphocytes, Regulatory / immunology*
  • Th17 Cells / immunology*
  • Therapy with Helminths / methods*

Substances

  • Antigens, Helminth
  • Cell Extracts
  • Cytokines
  • Myelin-Oligodendrocyte Glycoprotein
  • Receptors, Antigen, T-Cell, gamma-delta