Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study

Eur J Cancer Care (Engl). 2019 Jul;28(4):e13055. doi: 10.1111/ecc.13055. Epub 2019 Apr 24.


Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue.

Keywords: angiogenesis; biomarker; colorectal cancer; fatigue; inflammation.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Analysis of Variance
  • Biomarkers, Tumor / metabolism*
  • Body Mass Index
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / complications*
  • Colorectal Neoplasms / surgery
  • Fatigue / blood
  • Fatigue / etiology*
  • Female
  • Humans
  • Inflammation / blood
  • Male
  • Middle Aged
  • Neovascularization, Pathologic / blood
  • Postoperative Complications / blood
  • Postoperative Complications / etiology
  • Preoperative Care


  • Biomarkers, Tumor