Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

J Gene Med. 2019 Jun;21(6):e3093. doi: 10.1002/jgm.3093. Epub 2019 May 27.

Abstract

Background: Thyroid carcinoma accounts for a large part of endocrine neoplasia and the relationship between inflammation and thyroid cancer has been validated previously. Two known receptors of interleukin (IL)-1, IL-1 receptor 1 (IL1R1) and IL-1 receptor 2 (IL1R2), are implicated in numerous inflammatory responses. The present study aimed to assess the genetic polymorphisms of IL1R1 and IL1R2 with respect to thyroid cancer in the Chinese Han population.

Methods: Eleven single nucleotide polymorphisms of IL1R1 and IL1R2 were identified among 241 thyroid cancer patients and 463 controls using the Agena MassARRY method (http://www.internationalgenome.org). Genetic models and haplotype analysis were carried out to evaluate the significant links between the variants and the risk of thyroid cancer.

Results: Logistic regression analyses revealed significant associations of rs3917225, rs2072472 and rs11674595 with susceptibility to thyroid cancer. Haplotype analysis presented two blocks of IL1R2, whereas no statistical significance existed.

Conclusions: These findings suggested that rs3917225, rs2072472 and rs11674595 are risk factors associated with the development of thyroid carcinoma in Chinese Han people.

Keywords: Chinese Han population; IL1R1; IL1R2; association study; polymorphisms; thyroid cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Asian People / genetics
  • Case-Control Studies
  • China / epidemiology
  • Chromosome Mapping
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease*
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Polymorphism, Single Nucleotide*
  • Population Surveillance
  • Receptors, Interleukin-1 Type I / genetics*
  • Receptors, Interleukin-1 Type II / genetics*
  • Thyroid Neoplasms / epidemiology
  • Thyroid Neoplasms / genetics*
  • Thyroid Neoplasms / pathology

Substances

  • IL1R1 protein, human
  • IL1R2 protein, human
  • Receptors, Interleukin-1 Type I
  • Receptors, Interleukin-1 Type II