Interferon-gamma induces expression of the interleukin 2 receptor gene in human monocytes

Eur J Immunol. 1987 Jan;17(1):153-6. doi: 10.1002/eji.1830170127.


Interferon-gamma induces surface expression of interleukin 2 (IL2) receptors on human monocytes and the monocytic cell line U937. Freshly prepared peripheral blood monocytes and U937 cells were found to lack detectable IL 2 mRNA, but exposure of these cells to interferon-gamma induced IL 2 receptor message at 6 h of culture. At least two IL 2 receptor transcripts were detected (3.5 and 1.5 kb) in both monocytes and U937 cells, similar in size to IL 2 receptor transcripts in activated T cells. These results show that interferon-gamma induces expression of the monocyte IL 2 receptor gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Gene Expression Regulation / drug effects
  • Humans
  • Interferon-gamma / pharmacology*
  • Interleukin-2 / metabolism
  • Monocytes / metabolism*
  • RNA, Messenger / analysis
  • Receptors, Immunologic / biosynthesis*
  • Receptors, Immunologic / genetics
  • Receptors, Interleukin-2
  • Transcription, Genetic / drug effects


  • Interleukin-2
  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • Interferon-gamma