Systems Challenges of Hepatic Carcinomas: A Review

J Clin Exp Hepatol. 2019 Mar-Apr;9(2):233-244. doi: 10.1016/j.jceh.2018.05.002. Epub 2018 May 17.


Hepatocellular Carcinoma (HCC) is ubiquitous in its prevalence in most of the developing countries. In the era of systems biology, multi-omics has evinced an extensive approach to define the underlying mechanism of disease progression. HCC is a multifactorial disease and the investigation of progression of liver cirrhosis becomes much extensive with cultivating omics approaches. We have performed a comprehensive review about such challenges in multi-omics approaches that are concerned to identify the immunological, genetics and epidemiological factors associated with HCC.

Keywords: HBV, Hepatitis B Virus; HCC, Hepatocellular Carcinoma; HCV, Hepatitis B Virus; NAFLD, Non-Alcoholic Fatty Liver Disease; hepatocellular carcinoma; immunomodulators; signaling pathways; systems biology.

Publication types

  • Review