Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice

In Vivo. 2019 May-Jun;33(3):707-715. doi: 10.21873/invivo.11529.


Background/aim: The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models.

Materials and methods: C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue.

Results: OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis- and thermogenesis-related molecules was decreased in the OLE-treated group.

Conclusion: OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis.

Keywords: Obesity; adipogenesis; fat; olive leaf extract; thermogenesis.

MeSH terms

  • Adipogenesis / drug effects
  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Animals
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / pharmacology*
  • Biomarkers
  • Body Weight / drug effects
  • Diet, High-Fat / adverse effects
  • Disease Models, Animal
  • Lipid Metabolism
  • Male
  • Mice
  • Obesity / drug therapy
  • Obesity / etiology
  • Obesity / metabolism
  • Olea / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Thermogenesis / drug effects


  • Anti-Obesity Agents
  • Biomarkers
  • Plant Extracts