Tailored chromatin modulation to promote tissue regeneration

Semin Cell Dev Biol. 2020 Jan;97:3-15. doi: 10.1016/j.semcdb.2019.04.015. Epub 2019 May 2.

Abstract

Epigenetic regulation of gene expression is fundamental in the maintenance of cellular identity and the regulation of cellular plasticity during tissue repair. In fact, epigenetic modulation is associated with the processes of cellular de-differentiation, proliferation, and re-differentiation that takes place during tissue regeneration. In here we explore the epigenetic events that coordinate tissue repair in lower vertebrates with high regenerative capacity, and in mammalian adult stem cells, which are responsible for the homeostasis maintenance of most of our tissues. Finally we summarize promising CRISPR-based editing technologies developed during the last years, which look as promising tools to not only study but also promote specific events during tissue regeneration.

Keywords: Adult stem cells; CRISPR; DNA methylation; Epidermal stem cells; Epigenetic editing; Epigenetics; Genetic editing; Hematopoietic stem cells; Histone modifications; Intestinal stem cells; Muscle stem cells; Neural stem cells; Regeneration.

Publication types

  • Review

MeSH terms

  • Chromatin / metabolism*
  • Epigenesis, Genetic / genetics*
  • Humans
  • Regeneration / drug effects*

Substances

  • Chromatin