CuO/C nanocomposite: Synthesis and optimization using sucrose as carbon source and its antifungal activity

Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:404-414. doi: 10.1016/j.msec.2019.03.105. Epub 2019 Mar 30.


The synthesis of bioactive CuO/C nano composite using sucrose as a capping agent is achieved through simple green approach via Response Surface Methodology. The synthesis process was done in a green environment which prevents aggregation of sucrose and promotes nanoparticles formation. The innovative approach produces sucrose as a carbon source mediated copper oxide nanocomposites (CuO/C nanocomposite) with the particle size of 50 nm. Additionally, the produced CuO/C nanocomposite were characterized using microscopic techniques like SEM, TEM and spectroscopic techniques like UV-vis and X-ray diffraction. The antifungal activities of CuO/C nanocomposite were tested against Aspergillus niger and Aspergillus flavus species. At 1000 ppm of CuO/C nanocomposite, it showed 70% restraint on A. flavus and 90% hindrance on A. niger. The fungal inhibition mechanism of bioactive CuO/C nanocomposite was discussed in this research article. The particular high antifungal performance of CuO/C nanocomposite was found against Aspergillus niger while compare to Aspergillus flavus fungal strain.

Keywords: Antifungal activity; Capping agent; CuO/C nanocomposite; Green synthesis; Sucrose.

MeSH terms

  • Analysis of Variance
  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects
  • Carbon / pharmacology*
  • Copper / pharmacology*
  • Hemolysis / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Regression Analysis
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Sucrose / pharmacology*


  • Antifungal Agents
  • Sucrose
  • Carbon
  • Copper
  • cupric oxide