Two Forms of the T-cell Receptor Gamma Protein Found on Peripheral Blood Cytotoxic T Lymphocytes

Nature. 1987 Feb 19-25;325(6106):689-94. doi: 10.1038/325689a0.

Abstract

The T-cell receptor (TCR) gamma polypeptide is expressed associated with CD3 (T3) on the surface of normal human peripheral blood lymphocytes. These cells function as non-MHC-restricted cytotoxic T lymphocytes (CTL)and thus may play an important role in host immune defence. The TCR gamma polypeptide occurs as a dimer in at least two molecular forms based on the absence or presence of disulphide linkage. These forms use TCR gamma polypeptides with strikingly different peptide backbone sizes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface / immunology*
  • Cell Line
  • Clone Cells / immunology
  • DNA / genetics
  • Disulfides
  • Electrophoresis, Polyacrylamide Gel
  • Gene Expression Regulation
  • Humans
  • Immunosorbent Techniques
  • Macromolecular Substances
  • Nucleic Acid Hybridization
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Disulfides
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell
  • DNA