A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

Nature. 1987 Mar 5-11;326(6108):42-7. doi: 10.1038/326042a0.


Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of the cloned cDNAs can restore clock function to mutant arrhythmic flies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Clocks*
  • Circadian Rhythm
  • Cloning, Molecular
  • DNA / genetics
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / physiology
  • Exons
  • Genes
  • Introns
  • Mutation
  • Proteins / genetics
  • RNA Splicing*
  • RNA, Messenger / genetics*


  • Proteins
  • RNA, Messenger
  • DNA