Neuroimmune interactions in chronic pain - An interdisciplinary perspective

Brain Behav Immun. 2019 Jul;79:56-62. doi: 10.1016/j.bbi.2019.04.033. Epub 2019 Apr 25.


It is widely accepted that communication between the nervous and immune systems is involved in the development of chronic pain. At each level of the nervous system, immune cells have been reported to accompany and frequently mediate dysfunction of nociceptive circuitry; however the exact mechanisms are not fully understood. One way to speed up progress in this area is to increase interdisciplinary cross-talk. This review sets out to summarize what pain research has already learnt, or indeed might still learn, from examining peripheral and central nociceptive mechanisms using tools and perspectives from other fields like immunology, inflammation biology or the study of stress.

Keywords: Chronic pain; Neuroimmune interactions; Neuroinflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Pain / immunology*
  • Chronic Pain / physiopathology*
  • Humans
  • Immune System / physiopathology
  • Inflammation / physiopathology
  • Interdisciplinary Studies
  • Neuroimmunomodulation / immunology*
  • Neuroimmunomodulation / physiology*