Uterine carcinosarcoma: a primer for radiologists

Abdom Radiol (NY). 2019 Aug;44(8):2874-2885. doi: 10.1007/s00261-019-02038-8.


Objective: To provide a modern overview for radiologists of the unique radiological, pathological, and clinical features of uterine carcinosarcoma (UCS).

Results: UCS is a unique gynecological malignancy that continues to present diagnostic and therapeutic challenges to the field of oncology. The classification and clinical understanding of this malignancy have evolved in recent years, yielding a modern conceptualization of a neoplastic entity that has been well studied but incompletely understood. As UCS causes a significant proportion of deaths secondary to uterine cancer, developing a familiarity with the imaging and clinical features of this entity is critical. In addition to summarizing the modern understanding of this tumor variant, an overview of the common imaging features of UCS will be presented. The role of radiological staging, imaging findings on presentation and follow-up imaging, and modern treatment paradigms will be discussed. Lastly, the current treatment paradigms and surveillance recommendations for UCS will be summarized.

Conclusion: Knowledge of the modern understanding of uterine carcinosarcoma, including its relevant imaging and clinical features, is critical for radiologists.

Keywords: Carcinosarcoma; Diagnostic imaging; Endometrial cancer; Neoplasm staging; Radiologists; Uterine neoplasms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Carcinosarcoma / diagnostic imaging*
  • Carcinosarcoma / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Uterine Neoplasms / diagnostic imaging*
  • Uterine Neoplasms / pathology