Induction of human leukocyte antigen-A,B,C and -DR on cultured human oligodendrocytes and astrocytes by human gamma-interferon

Neurosci Lett. 1986 Dec 23;72(3):369-74. doi: 10.1016/0304-3940(86)90543-4.

Abstract

gamma-Interferon (IFN-gamma) is known to induce expression of major histocompatibility complex (MHC) class II antigens on murine astrocytes and MHC class I antigens on murine oligodendrocytes. We studied whether the human IFN-gamma could induce the expression of Human Leukocyte Antigen (HLA)-A, B, C and -DR antigens on cultured human glia from autopsied brain white matter tissue. HLA-A, B, C antigens were induced on both human astrocytes and oligodendrocytes, whereas HLA-DR antigens were induced only on some astrocytes. From these results, it is suggested that IFN-gamma affects the expression of MHC class I and class II antigens on astrocytes and oligodendrocytes derived from human brain. The relationship between the induction of MHC class I and class II antigens by IFN-gamma and the pathogenesis of multiple sclerosis is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Astrocytes / drug effects
  • Astrocytes / immunology*
  • Cells, Cultured
  • HLA Antigens / immunology*
  • HLA-D Antigens / immunology*
  • HLA-DR Antigens / immunology*
  • Humans
  • Interferon-gamma / pharmacology*
  • Neuroglia / immunology*
  • Oligodendroglia / drug effects
  • Oligodendroglia / immunology*

Substances

  • HLA Antigens
  • HLA-D Antigens
  • HLA-DR Antigens
  • Interferon-gamma