Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr 11;10:184.
doi: 10.3389/fpsyt.2019.00184. eCollection 2019.

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression

Affiliations
Free PMC article
Review

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression

Meidan Fang et al. Front Psychiatry. .
Free PMC article

Abstract

A considerable body of evidence has shown that inflammation plays an important role in the process of stroke rehabilitation and development of poststroke depression (PSD). However, the specific molecular and cellular mechanisms involved remain unclear. In this review, we summarize how neuroinflammation affects stroke rehabilitation and PSD. We mainly focus on the immune/inflammatory response, involving astrocytes, microglia, monocyte-derived macrophages, cytokines (tumor necrosis factor alpha, interleukin 1), and microRNAs (microRNA-124, microRNA 133b). This review provides new insights into the effect of inflammation on the process of stroke rehabilitation and PSD and potentially offer new therapeutic targets of stroke and PSD.

Keywords: immune/inflammation; pharmacotherapy; poststroke depression; rehabilitation; stroke.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Tuttolomondo A, Pecoraro R, Pinto A. Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date. Drug Design Dev Ther. (2014) 8:2221–38. 10.2147/DDDT.S67655 - DOI - PMC - PubMed
    1. Kriz J, Lalancette-Hébert M. Inflammation, plasticity and real-time imaging after cerebral ischemia. Acta Neuropathologica. (2009) 117:497–509. 10.1007/s00401-009-0496-1 - DOI - PubMed
    1. Neves JD, Aristimunha D, Vizuete AF, Nicola F, Vanzella C, Petenuzzo L, et al. . Glial-associated changes in the cerebral cortex after collagenase-induced intracerebral hemorrhage in the rat striatum. Brain Res Bull. (2017) 134:55–62. 10.1016/j.brainresbull.2017.07.002 - DOI - PubMed
    1. Nakase T, Tobisawa M, Sasaki M, Suzuki A. Outstanding symptoms of poststroke depression during the acute phase of stroke. PLoS ONE. (2016) 11:e0163038. 10.1371/journal.pone.0163038 - DOI - PMC - PubMed
    1. Levada OA, Troyan AS. Poststroke Depression biomarkers: a narrative review. Front Neurol. (2018) 9:577. 10.3389/fneur.2018.00577 - DOI - PMC - PubMed

LinkOut - more resources

Feedback