[Benign epileptic infantile spasms]

Rev Electroencephalogr Neurophysiol Clin. 1986 Dec;16(4):371-82. doi: 10.1016/s0370-4475(86)80027-2.
[Article in French]


Among 100 infants with infantile spasms studied before treatment, 14 had idiopathic spasms with a favourable outcome. They had a normal development, including reaching for objects before the age of 5 months and moderate regression without loss of eye following. Although it was hysarhythmic, the EEG tracing showed identifiable basic activity and sleep spindles; there was no slow waves focus even after diazepam administration and the spasms were "independent" even during a cluster. This type of infantile spasms seems to be a particular type of non-lesional epilepsy. It contrasts with idiopathic spasms of unfavourable outcome that apparently result from a preexisting and overlooked focal lesion responsible of later cognitive troubles.

Publication types

  • English Abstract

MeSH terms

  • Child, Preschool
  • Diazepam
  • Electroencephalography*
  • Follow-Up Studies
  • Humans
  • Hydrocortisone / therapeutic use
  • Infant
  • Intelligence
  • Spasms, Infantile / diagnosis*
  • Spasms, Infantile / drug therapy
  • Valproic Acid / therapeutic use


  • Valproic Acid
  • Diazepam
  • Hydrocortisone