Topical skin therapies in subjects undergoing full facial rejuvenation

J Cosmet Dermatol. 2019 Jun;18(3):798-805. doi: 10.1111/jocd.12977. Epub 2019 Apr 29.


Background: Cosmeceutical therapies including face washes, moisturizers, chemical peels and antioxidant formulations are intended to improve the esthetic appearance of skin. The use of these products as adjuncts to full facial rejuvenation with hyaluronic acid filler and abobotulinumtoxinA may improve cosmetic and socio-esthetic outcomes.

Objective: To characterize the effect of skin care products in subjects undergoing full facial rejuvenation with abobotulinumtoxinA and hyaluronic acid in improving facial skin appearance, patient satisfaction, and projected first impressions.

Methods: Twenty subjects were recruited and divided into two treatment groups. Subjects in Group A followed a standard skin care regimen, whereas subjects in Group B received a more robust skin care regimen including chemical peels and antioxidant formulations. All subjects underwent facial rejuvenation treatments with hyaluronic acid at Visit 2 and with abobotulinumtoxinA at Visit 7. Patient esthetic improvement, satisfaction, self-esteem, and first impression were evaluated via the Fitzpatrick Wrinkle Assessment Scale, Global Aesthetic Improvement Scale, Skin Quality Assessment, Heatherton & Polivy State Self-Esteem Scale, Subject Satisfaction Scale, and the First Impressions Questionnaire.

Results: Both treatment groups experienced significant improvements in the Skin Quality Assessment, Fitzpatrick Wrinkle Assessment Scale, Heatherton and Polivy State Self-Esteem Scale, and First Impressions Questionnaire.

Conclusion: The cosmeceutical therapies used in this study in combination with abobotulinumtoxinA and hyaluronic acid filler improved subjects' skin quality, self-esteem, and projected first impressions. Larger studies are needed to determine the most efficacious combination of topical skin therapies with facial rejuvenation therapy.

Keywords: botulinum toxin; epidermal growth factor; hyaluronic acid; l-ascorbic acid; tocopherol; trichloroacetic acid.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Botulinum Toxins, Type A / administration & dosage
  • Combined Modality Therapy / methods
  • Cosmeceuticals / administration & dosage
  • Cosmetic Techniques*
  • Dermal Fillers / administration & dosage
  • Face
  • Female
  • Healthy Volunteers
  • Humans
  • Hyaluronic Acid / administration & dosage
  • Injections, Subcutaneous
  • Middle Aged
  • Patient Satisfaction*
  • Rejuvenation*
  • Self Concept
  • Skin Aging / drug effects
  • Skin Care / methods*
  • Treatment Outcome


  • Cosmeceuticals
  • Dermal Fillers
  • Hyaluronic Acid
  • Botulinum Toxins, Type A
  • abobotulinumtoxinA

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