Effect of flavanone on mixed-function oxidase and conjugation reactions in rats

Xenobiotica. 1987 Jan;17(1):11-6. doi: 10.3109/00498258709047170.

Abstract

Flavanone administered to female Fischer 344 rats (1.00 mmol/kg per day for seven days) did not induce ethylmorphine demethylation, aniline hydroxylation, hexobarbital oxidation or aldrin epoxidation. Flavanone at 0.05 mmol/kg per day for seven days increased glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy) propane as substrates. Flavanone at 0.05 mmol/kg per day for seven days increased the glucuronidation of 1-naphthol, and at 0.20 mmol/kg increased the glucuronidation of chloramphenicol. Flavanone administration did not alter sulphotransferase activity with 2-naphthol as the substrate and did not enhance glutathione-S-transferase or glucuronyltransferase activity when added in vitro.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biotransformation / drug effects*
  • Flavanones*
  • Flavonoids / pharmacology*
  • Glucuronosyltransferase / metabolism*
  • Glutathione Transferase / metabolism*
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / metabolism*
  • Rats

Substances

  • Flavanones
  • Flavonoids
  • Mixed Function Oxygenases
  • Glucuronosyltransferase
  • Glutathione Transferase
  • flavanone