Abstract
Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.
MeSH terms
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Anti-HIV Agents / administration & dosage*
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Anti-HIV Agents / adverse effects
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Drug-Related Side Effects and Adverse Reactions / epidemiology
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Drug-Related Side Effects and Adverse Reactions / prevention & control*
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Female
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HIV Infections / prevention & control*
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Hematologic Diseases / chemically induced*
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Hematologic Diseases / epidemiology*
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Humans
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Infant
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Infant, Newborn
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Infectious Disease Transmission, Vertical / prevention & control*
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Male
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Pregnancy
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Retrospective Studies
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Zidovudine / administration & dosage*
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Zidovudine / adverse effects
Substances
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Anti-HIV Agents
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Zidovudine