Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

Pediatr Infect Dis J. 2019 Sep;38(9):e219-e222. doi: 10.1097/INF.0000000000002354.


We report a case of lower respiratory tract infection with human bocavirus 1 (HboV1) in an immunodeficient 6-month-old boy leading to respiratory failure with fatal outcome. Polymerase chain reaction of serum/tracheal secretions revealed exceptionally high HboV1-DNA levels and immunoassays showed seroconversion indicating an acute primary HboV1 infection. All assays for other pathogens were negative, strongly suggesting that HboV1 was the causative agent in this case.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Viral / genetics
  • Fatal Outcome
  • Human bocavirus / genetics
  • Human bocavirus / pathogenicity*
  • Humans
  • Immunocompromised Host*
  • Infant
  • Male
  • Molecular Diagnostic Techniques
  • Parvoviridae Infections / diagnosis*
  • Parvoviridae Infections / virology
  • Respiratory Tract Infections / diagnosis*
  • Respiratory Tract Infections / virology
  • Severity of Illness Index
  • Virus Shedding


  • DNA, Viral