The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action

Int J Sport Nutr Exerc Metab. 2019 Jul 1;29(4):354–358. doi: 10.1123/ijsnem.2018-0377.


The unique lactic acid bacteria, Lactococcus lactis strain plasma (LC-Plasma), stimulates plasmacytoid dendritic cells, which play an important role in viral infection. The authors previously reported that LC-Plasma reduced the number of days athletes experienced cold-like symptoms and fatigue feelings after high-intensity exercise training; however, the mechanism was unclear. In this study, the authors investigated the effect of LC-Plasma on recovery from physical damage after single exercise on a treadmill in BALB/c mice model. Oral administration of LC-Plasma (AIN-93G + 0.029% LC-Plasma) for 4 weeks significantly improved the locomotor reduction after treadmill exercise. This effect was not detected in mice receiving Lactobacillus rhamnosus GG, representative probiotics strain. LC-Plasma also improved voluntary locomotor activity after exercise. Blood and muscle sample analysis indicated that LC-Plasma affects plasmacytoid dendritic cell activation, which, in turn, attenuates muscle degenerative genes and the concentration of fatigue-controlled cytokine transforming growth factor-β.

Keywords: LC-Plasma; locomotor activity; treadmill exercise.

MeSH terms

  • Administration, Oral
  • Animals
  • Dendritic Cells / cytology*
  • Dendritic Cells / microbiology
  • Fatigue*
  • Lactobacillales / physiology
  • Lactococcus lactis / physiology*
  • Mice, Inbred BALB C
  • Motor Activity
  • Muscle, Skeletal / physiology*
  • Physical Conditioning, Animal / physiology*
  • Probiotics
  • Transforming Growth Factor beta1 / blood


  • Tgfb1 protein, mouse
  • Transforming Growth Factor beta1