Cerebral glucose metabolism in the Lennox-Gastaut syndrome

Ann Neurol. 1987 Jan;21(1):14-21. doi: 10.1002/ana.410210105.


We used positron emission tomography with fluorine 18-labeled 2-deoxyglucose to study cerebral glucose metabolism in 10 patients with Lennox-Gastaut syndrome who had normal neuroradiological studies. The scans showed decreased metabolic rates relative both to those in the caudate nucleus and to normal control values in 3 patients whose seizures began before the age of 1, as well as in a patient with hyperprolinemia. No patient had a region of persistent focal hypometabolism. Metabolic rates increased in parallel with increased electroencephalographic discharges in 1 patient; 3 patients had lower metabolic rates when the electroencephalogram showed epileptiform discharges and while the patients were taking barbiturates.

MeSH terms

  • Adolescent
  • Anticonvulsants / therapeutic use
  • Brain / metabolism*
  • Child
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / metabolism
  • Electroencephalography
  • Epilepsy, Absence / diagnosis
  • Epilepsy, Absence / drug therapy
  • Epilepsy, Absence / metabolism*
  • Fluorodeoxyglucose F18
  • Glucose / metabolism*
  • Humans
  • Syndrome
  • Tomography, Emission-Computed
  • Tomography, X-Ray Computed


  • Anticonvulsants
  • Fluorodeoxyglucose F18
  • Deoxyglucose
  • Glucose