The Lennox-Gastaut syndrome: metabolic subtypes determined by 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography

Ann Neurol. 1987 Jan;21(1):4-13. doi: 10.1002/ana.410210104.


We employed positron emission tomography (PET) with 2-deoxy-2[18F]fluoro-D-glucose (FDG) to study local cerebral glucose utilization in 15 children who had Lennox-Gastaut syndrome. Our results show that LGS can be classified into four predominant subtypes, each with a distinct metabolic pattern: unilateral focal hypometabolism, unilateral diffuse hypometabolism, bilateral diffuse hypometabolism, and normal. Functional disturbances seen on FDG-PET did not always correlate with abnormalities revealed by x-ray computed tomographic scan. This classification of Lennox-Gastaut syndrome into four major metabolic subtypes not only provides a new perspective toward understanding cerebral function in this complex syndrome, but may also prove useful in the clinical management of these patients.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / metabolism*
  • Child
  • Child, Preschool
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / metabolism
  • Diagnosis, Differential
  • Electroencephalography
  • Epilepsy, Absence / classification
  • Epilepsy, Absence / diagnosis
  • Epilepsy, Absence / metabolism*
  • Female
  • Fluorodeoxyglucose F18
  • Glucose / metabolism*
  • Humans
  • Male
  • Syndrome
  • Tomography, Emission-Computed


  • Fluorodeoxyglucose F18
  • Deoxyglucose
  • Glucose