Olive Leaf Extract (OleaVita) Suppresses Inflammatory Cytokine Production and NLRP3 Inflammasomes in Human Placenta

Nutrients. 2019 Apr 28;11(5):970. doi: 10.3390/nu11050970.


The placenta is essential for pregnancy and produces both pro-inflammatory and anti-inflammatory cytokines. Excessive production of inflammatory cytokines, involving interleukin-1β (IL-1β), IL-6, and IL-8, from placental tissues is associated with pregnancy complications. Olive leaf extract has several health benefits, including anti-inflammatory functions. OleaVita is a new commercial olive leaf extract; it is hypothesized to suppress placental inflammation. In human placental tissue culture, OleaVita treatment inhibited the secretion of inflammatory cytokines and NF-κB p65 protein expression. OleaVita also suppressed toll-like receptor ligands-induced IL-1β secretion in human placental tissues. IL-1β is regulated by the NLRP3 inflammasomes, a pivotal regulator of various diseases. OleaVita significantly decreased NLRP3 and pro-IL-1β protein expression, suggesting that it has an inhibitory effect on NLRP3 inflammasome activation. Thus, OleaVita is beneficial as an inhibitor of inflammation and NLRP3 inflammasome activation, and may be used as a supplement for the treatment and prevention of inflammatory diseases.

Keywords: NLRP3 inflammasome; inflammation; interleukin; placenta.

MeSH terms

  • Cytokines / genetics
  • Cytokines / metabolism*
  • Female
  • Gene Expression Regulation / drug effects*
  • Humans
  • NLR Family, Pyrin Domain-Containing 3 Protein / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
  • Olea / chemistry*
  • Placenta / drug effects*
  • Plant Extracts / pharmacology*
  • Pregnancy
  • Tissue Culture Techniques


  • Cytokines
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Plant Extracts