Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction

doi:10.3390/jcm8050570

. 2019 Apr 26;8(5):570.

doi: 10.3390/jcm8050570.

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction

Affiliations

¹ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. giulia.gagno@studenti.units.it.
² Sport and Exercise Medicine Division, Department of Medicine, University of Padova, 35122 Padova, Italy. argonauta92@hotmail.it.
³ Unique Laboratory of ASUITs, Burlo, Gorizia and Monfalcone, Azienda Sanitaria Universitaria di Trieste, 34100 Trieste, Italy. elisabetta.stenner@asuits.sanita.fvg.it.
⁴ Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy. ale.beleu@gmail.com.
⁵ Institute for Maternal and Child Health⁻IRCCS "Burlo Garofolo" Trieste and University of Trieste, 34100 Trieste, Italy. fabyz1@alice.it.
⁶ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. cristina.hiche@asuits.sanita.fvg.it.
⁷ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. alessiapaldino@gmail.com.
⁸ Biostatistics Unit, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy. giulia_barbati@yahoo.it.
⁹ Unit of Clinica Medica Generale e Terapia Medica, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy. biolo@units.it.
¹⁰ Unit of Clinica Medica Generale e Terapia Medica, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy. fiotti@units.it.
¹¹ Institute for Maternal and Child Health⁻IRCCS "Burlo Garofolo" Trieste and University of Trieste, 34100 Trieste, Italy. tnot@units.it.
¹² Department of Medicine (DAME), University of Udine, 33100 Udine, Italy. antonio.beltrami@uniud.it.
¹³ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. gianfranco.sinagra@asuits.sanita.fvg.it.
¹⁴ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. aaleksova@units.it.

PMID: 31035456
PMCID: PMC6571589
DOI: 10.3390/jcm8050570

Free PMC article

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction

Giulia Gagno et al. J Clin Med. 2019.

Free PMC article

. 2019 Apr 26;8(5):570.

doi: 10.3390/jcm8050570.

Authors

Affiliations

¹ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. giulia.gagno@studenti.units.it.
² Sport and Exercise Medicine Division, Department of Medicine, University of Padova, 35122 Padova, Italy. argonauta92@hotmail.it.
³ Unique Laboratory of ASUITs, Burlo, Gorizia and Monfalcone, Azienda Sanitaria Universitaria di Trieste, 34100 Trieste, Italy. elisabetta.stenner@asuits.sanita.fvg.it.
⁴ Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy. ale.beleu@gmail.com.
⁵ Institute for Maternal and Child Health⁻IRCCS "Burlo Garofolo" Trieste and University of Trieste, 34100 Trieste, Italy. fabyz1@alice.it.
⁶ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. cristina.hiche@asuits.sanita.fvg.it.
⁷ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. alessiapaldino@gmail.com.
⁸ Biostatistics Unit, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy. giulia_barbati@yahoo.it.
⁹ Unit of Clinica Medica Generale e Terapia Medica, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy. biolo@units.it.
¹⁰ Unit of Clinica Medica Generale e Terapia Medica, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy. fiotti@units.it.
¹¹ Institute for Maternal and Child Health⁻IRCCS "Burlo Garofolo" Trieste and University of Trieste, 34100 Trieste, Italy. tnot@units.it.
¹² Department of Medicine (DAME), University of Udine, 33100 Udine, Italy. antonio.beltrami@uniud.it.
¹³ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. gianfranco.sinagra@asuits.sanita.fvg.it.
¹⁴ Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy. aaleksova@units.it.

PMID: 31035456
PMCID: PMC6571589
DOI: 10.3390/jcm8050570

Abstract

Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting.

Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina/AMI and all-cause mortality at 12 months after the index event.

Results: In total, 469 patients were included. The median Gal-3bp was 9.1 μg/mL (IQR 5.8-13.5 μg/mL), while median Gal-3 was 9.8 ng/mL (IQR 7.8-12.8 ng/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients' age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78-0.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality.

Conclusions: The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI.

Keywords: Galectin 3; Galectin 3 binding protein; angina; ischemic cardiomyopathy; mortality; myocardial infarction; outcome; recurrent ischemic events; reinfarction.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Curves of the cumulative incidence of events.

**Figure 2**
ROC curve of our multivariate model compared to the ROC curve of the GRACE score for mortality at 1 year.

See this image and copyright information in PMC

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[8] O’Donoghue M.L., Morrow D.A., Cannon C.P., Jarolim P., Desai N.R., Sherwood M.W., Murphy S.A., Gerszten R.E., Sabatine M.S. Multimarker Risk Stratification in Patients with Acute Myocardial Infarction. J. Am. Heart. Assoc. 2016;5 doi: 10.1161/JAHA.115.002586. - DOI - PMC - PubMed

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Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction

Affiliations

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

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Abstract

Conflict of interest statement

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