Psychometric analysis of the adult sickle cell quality of life measurement information system (ACSQ-Me) in a UK population

Health Qual Life Outcomes. 2019 Apr 29;17(1):74. doi: 10.1186/s12955-019-1136-7.


Background: The Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me) has been shown to be a reliable and valid questionnaire measuring health-related quality of life (HRQoL) in the US sickle cell disease (SCD) population. The study objective was to test the validity and reliability of the ASCQ-Me for use in the UK.

Methods: The US ASCQ-Me, Hospital Anxiety and Depression Scale (HADS), self-reported symptoms, and Medical Outcome Survey Short Form 36 (SF-36) were administered to 173 patients with SCD. Clinical severity was assessed by the number of painful episodes indicated by hospital admissions.

Results: The results showed that the item banks of the UK ASCQ-Me had good internal consistency. Anxiety and depression were strongly correlated with the emotional, and social item banks of the UK ASCQ-Me, with moderate correlations between the UK ASCQ-Me item banks and SF-36 components suggesting convergent validity. A confirmatory factor analysis confirmed the conceptual framework of the scale as being the same as the US ASCQ-Me, indicating construct validity. Known groups validity was found, with the ASCQ-Me being able to differentiate by SCD severity groups.

Conclusion: The analysis of the sample shows evidence of both validity and reliability of the ASCQ-Me for use in the UK SCD population.

Keywords: ASCQ-Me; Quality of life; SF-36; Sickle cell disease; Validity.

Publication types

  • Validation Study

MeSH terms

  • Adult
  • Anemia, Sickle Cell / psychology*
  • Anxiety / psychology
  • Depression / psychology
  • Factor Analysis, Statistical
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Reported Outcome Measures*
  • Psychometrics
  • Quality of Life*
  • Reproducibility of Results
  • Severity of Illness Index
  • United Kingdom