The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis

Pancreatology. 2019 Jun;19(4):531-534. doi: 10.1016/j.pan.2019.04.006. Epub 2019 Apr 26.

Abstract

Objectives: It has previously been reported in a European case-control study with patients from Germany and France that CEL-HYB1, a hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene CELP, increases susceptibility to chronic pancreatitis (CP). Here, we aimed to replicate this finding in Polish pediatric patients with CP.

Method: The distribution of the CEL-HYB1 allele in a CP pediatric cohort (n = 147, median age at CP onset 7.6 years) with no history of alcohol/smoking abuse was compared with ethnically matched healthy controls (n = 500, median age 46 years). Screening was performed using long-range PCR followed by agarose gel-electrophoresis.

Results: We observed no significant difference in the carrier frequency of the CEL-HYB1 allele between CP patients (7/147, 4.8%) and controls (12/500, 2.4%; P = 0.16).

Conclusions: This study found no statistically significant association between CEL-HYB1 and chronic pancreatitis in a cohort of Polish pediatric CP patients.

Keywords: CEL-HYB1 allele; Chronic pancreatitis.

MeSH terms

  • Adolescent
  • Age of Onset
  • Alleles
  • Carrier State
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Gene Frequency
  • Humans
  • Infant
  • Lipase / genetics*
  • Male
  • Pancreatitis, Chronic / epidemiology*
  • Pancreatitis, Chronic / genetics*
  • Poland / epidemiology
  • Polymerase Chain Reaction

Substances

  • CEL protein, human
  • Lipase