Purpose of review: Current research is examining predictors of the transition to psychosis in youth who are at clinical high risk based on attenuated psychotic symptoms (APS). Determining predictors of the development of psychosis is important for an improved understanding of mechanisms as well as the development of preventative strategies. The purpose is to review the most recent literature identifying predictors of the transition to psychosis in those who are already assessed as being at risk.
Recent findings: Multidomain models, in particular, integrated models of symptoms, social functioning, and cognition variables, achieve better predictive performance than individual factors. There are many methodological issues; however, several solutions have now been described in the literature. For youth who already have APS, predicting who may go on to later develop psychosis is possible. Several studies are underway in large consortiums that may overcome some of the methodological concerns and develop improved means of prediction.
Keywords: Clinical high risk; Prodrome; Psychosis; Risk factors; Schizophrenia, predictors.
The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic SymptomsJ Addington et al. Schizophr Bull 43 (1), 57-63. PMID 27798225.In the literature, there have been several attempts to develop prediction models for youth who are at clinical high risk (CHR) of developing psychosis. Although there are …
Clinical and Functional Characteristics of Youth at Clinical High-Risk for Psychosis Who Do Not Transition to PsychosisJ Addington et al. Psychol Med 49 (10), 1670-1677. PMID 30176955.A detailed examination of the clinical and functional outcomes of those who did not make the transition to psychosis did not contribute to predicting who may make the tra …
Prediction of Psychosis in Youth at High Clinical Risk: A Multisite Longitudinal Study in North AmericaTD Cannon et al. Arch Gen Psychiatry 65 (1), 28-37. PMID 18180426.These findings demonstrate that prospective ascertainment of individuals at risk for psychosis is feasible, with a level of predictive accuracy comparable to that in othe …
Prediction of Conversion to Psychosis in Individuals With an At-Risk Mental State: A Brief Update on Recent DevelopmentsA Riecher-Rössler et al. Curr Opin Psychiatry 30 (3), 209-219. PMID 28212173. - ReviewPrediction of psychosis is already possible with an excellent prognostic performance based on clinical assessments. Recent studies show that this accuracy can be further …
Early Psychotic Experiences: Interventions, Problems and PerspectivesS Dimitrakopoulos et al. Psychiatriki 26 (1), 45-54. PMID 25880383. - ReviewPsychotic or psychotic-like experiences and symptoms may precede and be indicative of later psychosis emergence. DSM-5 has introduced Attenuated Psychosis Syndrome (APS) …
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Assessing Developmental Environmental Risk Factor Exposure in Clinical High Risk for Psychosis Individuals: Preliminary Results Using the Individual and Structural Exposure to Stress in Psychosis-Risk States ScaleT Vargas et al. J Clin Med 8 (7). PMID 31323940.Significant group differences were not observed for lifetime cumulative events, though CHR trended toward endorsing more events and greater stress severity. For stress se …