Radiation-induced anaplastic astrocytoma following treatment of medulloblastoma

Folia Neuropathol. 2019;57(1):80-86. doi: 10.5114/fn.2019.83834.


We hereby report a case of a 10-year-old girl in whom neurosurgery was performed for cerebellar vermis medulloblastoma in April 2000. After resection the patient underwent chemotherapy followed by radiotherapy, receiving 53.07 Gy to posterior fossa and 35.07 Gy to the rest of the craniospinal axis. In 2012, she was diagnosed with anaplastic astrocytoma, which was located within the high-dose region. Surgical resection of the tumour was performed. Postoperatively, the patient received radiation therapy (50.4 Gy) with concurrent temozolomide, followed by 6 cycles of adjuvant temozolomide. Five years after the diagnosis of anaplastic astrocytoma, the patient remains asymptomatic.

Keywords: anaplastic astrocytoma; chemoradiotherapy; radiation-induced tumour; reirradiation; medulloblastoma.

Publication types

  • Case Reports

MeSH terms

  • Astrocytoma / etiology*
  • Brain Neoplasms / etiology*
  • Cerebellar Neoplasms / radiotherapy*
  • Child
  • Cranial Irradiation / adverse effects
  • Female
  • Humans
  • Medulloblastoma / radiotherapy*
  • Neoplasms, Radiation-Induced*