An association between anti-inflammatory medication and internal pelvic fistulas

Dis Colon Rectum. 1987 Mar;30(3):168-70. doi: 10.1007/BF02554329.


Spontaneous internal fistulas involving intestine, rectum, bladder, or vagina in patients without predisposing illnesses were studied. Twelve of 20 (60 percent) were receiving steroids or other anti-inflammatory medication at the time the fistulas developed. Fifteen of the 20 patients subsequently had diverticular disease identified. It is proposed that there is an association between anti-inflammatory medication and fistulas that develop from intestine to other pelvic viscera, spontaneously or in association with colonic diverticula.

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Diverticulum / complications
  • Female
  • Fistula / chemically induced*
  • Humans
  • Male
  • Middle Aged
  • Pelvis*
  • Steroids


  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Steroids