The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health

. 2018 Aug;17(4):28-32.

The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health

Jeremy Appleton

PMID: 31043907
PMCID: PMC6469458

The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health

Jeremy Appleton. Integr Med (Encinitas). 2018 Aug.

. 2018 Aug;17(4):28-32.

Author

Jeremy Appleton

PMID: 31043907
PMCID: PMC6469458

Abstract

The gut-brain axis is a bidirectional communication network that links the enteric and central nervous systems. This network is not only anatomical, but it extends to include endocrine, humoral, metabolic, and immune routes of communication as well. The autonomic nervous system, hypothalamic-pituitary-adrenal (HPA) axis, and nerves within the gastrointestinal tract, all link the gut and the brain, allowing the brain to influence intestinal activities, including activity of functional immune effector cells; and the gut to influence mood, cognition, and mental health.

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References

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[1] Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203-209. - PMC - PubMed

[2] Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203-209. - PMC - PubMed

[3] Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014;146:1500-1512. - PMC - PubMed

[4] Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014;146:1500-1512. - PMC - PubMed

[5] Kennedy PJ, Clarke G, Quigley EM, Groeger JA, Dinan TG, Cryan JF. Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome. Neurosci Biobehav Rev. 2012;36:310-340. - PubMed

[6] Kennedy PJ, Clarke G, Quigley EM, Groeger JA, Dinan TG, Cryan JF. Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome. Neurosci Biobehav Rev. 2012;36:310-340. - PubMed

[7] Mayer EA. Gut feelings: The emerging biology of gut-brain communication. Nat Rev Neurosci. 2011;12:453-466. - PMC - PubMed

[8] Mayer EA. Gut feelings: The emerging biology of gut-brain communication. Nat Rev Neurosci. 2011;12:453-466. - PMC - PubMed

[9] Moloney RD, Desbonnet L, Clarke G, et al. The microbiome: stress, health and disease. Mamm Genome. 2014;25(1-2):49-74. - PubMed

[10] Moloney RD, Desbonnet L, Clarke G, et al. The microbiome: stress, health and disease. Mamm Genome. 2014;25(1-2):49-74. - PubMed

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The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health

The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health

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