Reduction in Obsessive Compulsive Disorder and Self-Injurious Behavior With Saccharomyces boulardii in a Child with Autism: A Case Report
- PMID: 31043927
- PMCID: PMC6469440
Reduction in Obsessive Compulsive Disorder and Self-Injurious Behavior With Saccharomyces boulardii in a Child with Autism: A Case Report
Abstract
This case report describes the effective use of Saccharomyces boulardii in a boy with autism spectrum disorder, obsessive compulsive disorder (OCD), and self-injurious behavior (SIB). Gastrointestinal dysfunction and OCD are frequent comorbidities in autism, which may share a common etiology resulting from a disturbance in normal gut microbiota. Alterations in microbial diversity influence neuroinflammation and are linked to mood disorders, abdominal pain, and SIB. S boulardii is a nonpathogenic probiotic yeast that supports a healthy microbiome, enhances immune function, and reduces diarrhea. Treatment with S boulardii successfully reduced OCD and SIB symptoms in this child.
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References
-
- McElhanon BO, McCracken C, Karpen S, Sharp WG. Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics. 2014;133(5):872-883. - PubMed
-
- Grossi E, Terruzzi V. The role of intestinal dysbiosis in the pathogenesis of autism: Minireview.” Int J Microbiol Adv Immunol. 2014;2:41-44.
-
- Li Q, Zhou J-M. The microbiota–gut–brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience. 2016;324:131-139. - PubMed
-
- Courtemanche AB, Black WR, Matthew Reese R. The relationship between pain, self-injury, and other problem behaviors in young children with autism and other developmental disabilities. Am J Intellect Development Disabil. 2016;121(3);194-203. - PubMed
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