Abstract
Acetaminophen, a popular NSAID (Non-steroidal anti-inflammatory drug), was studied for efficacy of removal from aqueous solutions. While Octolig® (a polyethylenediimine covalently attached to silica gel) is able to remove many simple anions and some acidic pharmaceuticals having a pKa value less than 4.5, it lacked efficacy with acetaminophen. Accordingly different transition- metal derivatives of Octolig® were tested by column chromatography using as substrates Octolig® derivatives of copper(II), cobalt(II), iron(III), manganese(II), nickel(II), and zinc(II).
Keywords:
Acetaminophen; NSAIDs; Octolig®; aqueous; removal; transition metal ions.
MeSH terms
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Acetaminophen / isolation & purification
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Acetaminophen / pharmacokinetics
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Anions
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
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Chromatography / methods
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Cobalt / chemistry
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Copper / chemistry
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Ferric Compounds / chemistry
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Humans
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Manganese / chemistry
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Nickel / chemistry
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Polyethylenes / chemistry
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Silica Gel / chemistry*
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Silica Gel / metabolism
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Solutions / chemistry
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Water / chemistry*
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Water Pollutants, Chemical / isolation & purification*
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Water Pollutants, Chemical / pharmacokinetics
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Water Purification / methods*
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Zinc / chemistry
Substances
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Anions
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Anti-Inflammatory Agents, Non-Steroidal
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Ferric Compounds
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Polyethylenes
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Solutions
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Water Pollutants, Chemical
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Water
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Acetaminophen
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Cobalt
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Manganese
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Silica Gel
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Copper
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Nickel
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Zinc