Efficacy of removal of a popular NSAID from aqueous solutions with metalloligs

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019;54(8):782-785. doi: 10.1080/10934529.2019.1593742. Epub 2019 May 3.

Abstract

Acetaminophen, a popular NSAID (Non-steroidal anti-inflammatory drug), was studied for efficacy of removal from aqueous solutions. While Octolig® (a polyethylenediimine covalently attached to silica gel) is able to remove many simple anions and some acidic pharmaceuticals having a pKa value less than 4.5, it lacked efficacy with acetaminophen. Accordingly different transition- metal derivatives of Octolig® were tested by column chromatography using as substrates Octolig® derivatives of copper(II), cobalt(II), iron(III), manganese(II), nickel(II), and zinc(II).

Keywords: Acetaminophen; NSAIDs; Octolig®; aqueous; removal; transition metal ions.

Publication types

  • Evaluation Study

MeSH terms

  • Acetaminophen / isolation & purification
  • Acetaminophen / pharmacokinetics
  • Anions
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Chromatography / methods
  • Cobalt / chemistry
  • Copper / chemistry
  • Ferric Compounds / chemistry
  • Humans
  • Manganese / chemistry
  • Nickel / chemistry
  • Polyethylenes / chemistry
  • Silica Gel / chemistry*
  • Silica Gel / metabolism
  • Solutions / chemistry
  • Water / chemistry*
  • Water Pollutants, Chemical / isolation & purification*
  • Water Pollutants, Chemical / pharmacokinetics
  • Water Purification / methods*
  • Zinc / chemistry

Substances

  • Anions
  • Anti-Inflammatory Agents, Non-Steroidal
  • Ferric Compounds
  • Polyethylenes
  • Solutions
  • Water Pollutants, Chemical
  • Water
  • Acetaminophen
  • Cobalt
  • Manganese
  • Silica Gel
  • Copper
  • Nickel
  • Zinc