Neuropsychological perspectives in amyotrophic lateral sclerosis

Neurol Clin. 1987 Feb;5(1):61-81.


Three aspects of neuropsychological functioning in patients with ALS are examined. Contrary to previous research, a new psychometric study of psychological adjustment suggested significant depression-distress in this population and related psychological disturbance differentially to signs of upper versus lower motor neuron involvement and to respiratory failure. An association between ALS and impaired neuropsychological functioning is discussed through an examination of the clinical and pathologic literatures. ALS appears to be a multisystem degenerative disease with a variety of expressions that may frequently include loss of cognitive-behavioral competency with progressive involvement of the prefrontal cortex and, in a few instances, profound dementia. Finally, the article describes an analysis of trends in psychological adjustment and in the perception of physical capability over the course of a pilot clinical trial.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Adaptation, Psychological
  • Adult
  • Amyotrophic Lateral Sclerosis / drug therapy
  • Amyotrophic Lateral Sclerosis / psychology*
  • Clinical Trials as Topic
  • Cognition Disorders / psychology
  • Dementia / psychology
  • Emotions
  • Female
  • Humans
  • MMPI
  • Male
  • Middle Aged
  • Neuropsychology
  • Psychological Tests
  • Thyrotropin-Releasing Hormone / therapeutic use


  • Thyrotropin-Releasing Hormone