Cellular functions of long noncoding RNAs

doi:10.1038/s41556-019-0311-8

Review

. 2019 May;21(5):542-551.

doi: 10.1038/s41556-019-0311-8. Epub 2019 May 2.

Cellular functions of long noncoding RNAs

Run-Wen Yao^#¹, Yang Wang^#¹, Ling-Ling Chen^{2

3}

Affiliations

¹ State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
² State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. linglingchen@sibcb.ac.cn.
³ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. linglingchen@sibcb.ac.cn.

^# Contributed equally.

PMID: 31048766
DOI: 10.1038/s41556-019-0311-8

Review

Cellular functions of long noncoding RNAs

Run-Wen Yao et al. Nat Cell Biol. 2019 May.

. 2019 May;21(5):542-551.

doi: 10.1038/s41556-019-0311-8. Epub 2019 May 2.

Authors

Run-Wen Yao^#¹, Yang Wang^#¹, Ling-Ling Chen^{2

3}

Affiliations

¹ State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
² State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. linglingchen@sibcb.ac.cn.
³ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. linglingchen@sibcb.ac.cn.

^# Contributed equally.

PMID: 31048766
DOI: 10.1038/s41556-019-0311-8

Abstract

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.

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References

1. Djebali, S. et al. Landscape of transcription in human cells. Nature 489, 101–108 (2012). - PubMed - PMC
1. Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775–1789 (2012). - PubMed - PMC
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1. Wilusz, J. E., Freier, S. M. & Spector, D. L. 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 135, 919–932 (2008). - PubMed - PMC
1. Sunwoo, H. et al. MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 19, 347–359 (2009). - PubMed - PMC

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[1] Djebali, S. et al. Landscape of transcription in human cells. Nature 489, 101–108 (2012). - PubMed - PMC

[2] Djebali, S. et al. Landscape of transcription in human cells. Nature 489, 101–108 (2012). - PubMed - PMC

[3] Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775–1789 (2012). - PubMed - PMC

[4] Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775–1789 (2012). - PubMed - PMC

[5] Katayama, S. et al. Antisense transcription in the mammalian transcriptome. Science 309, 1564–1566 (2005).

[6] Katayama, S. et al. Antisense transcription in the mammalian transcriptome. Science 309, 1564–1566 (2005).

[7] Wilusz, J. E., Freier, S. M. & Spector, D. L. 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 135, 919–932 (2008). - PubMed - PMC

[8] Wilusz, J. E., Freier, S. M. & Spector, D. L. 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 135, 919–932 (2008). - PubMed - PMC

[9] Sunwoo, H. et al. MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 19, 347–359 (2009). - PubMed - PMC

[10] Sunwoo, H. et al. MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 19, 347–359 (2009). - PubMed - PMC

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Cellular functions of long noncoding RNAs

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