Abstract
In an effort to devise an alternative treatment for human ovarian cancer, we have isolated a monoclonal antibody (OVB-3) that reacts with all ovarian cancers tested (10/10) but few normal tissues. An immunotoxin produced by coupling OVB-3 to Pseudomonas exotoxin kills ovarian cancer cells in tissue culture and prolongs the life of animals bearing human ovarian cancers. These data suggest that this immunotoxin should be evaluated as a treatment for ovarian cancer in women.
MeSH terms
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ADP Ribose Transferases*
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Animals
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Antibodies, Monoclonal / therapeutic use*
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Bacterial Toxins*
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Cell Line
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Exotoxins / therapeutic use*
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Female
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Humans
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Immunotherapy
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Liver / pathology
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Mice
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Neoplasm Transplantation
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Ovarian Neoplasms / pathology
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Ovarian Neoplasms / therapy*
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Pseudomonas aeruginosa
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Pseudomonas aeruginosa Exotoxin A
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Transplantation, Heterologous
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Virulence Factors*
Substances
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Antibodies, Monoclonal
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Bacterial Toxins
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Exotoxins
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Virulence Factors
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ADP Ribose Transferases