Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure

Cell Stem Cell. 2019 May 2;24(5):685-687. doi: 10.1016/j.stem.2019.04.010.


Recently in Nature, Gupta et al. (2019) reported that a second patient has achieved HIV-1 remission/functional cure after allogeneic hematopoietic stem cell transplantation from a donor carrying a mutation in the CCR5 coreceptor. We highlight both patients' treatments and summarize efforts to develop a broader, more patient-friendly approach.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Berlin
  • Genetic Therapy
  • HIV Infections*
  • HIV-1*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • London
  • Receptors, CCR5


  • Receptors, CCR5